The Proteomics Center at Stony Brook (formerly the Center for the Analysis and Synthesis of Macromolecules, CASM) was established in the Health Sciences Center at the University at Stony Brook in 1985 with a Shared Instrumentation Grant from the National Institutes of Health. The Proteomics Core Facility at Stony Brook University School of Medicine supports basic and clinical research programs by performing mass spectrometry-based analyses of proteins and peptides. The facility offers state-of-the-art instrumentation and software for qualitative (e.g. protein identification), quantitative proteomics analysis (e.g. relative quantification), and post-translational modification (PTM) analysis. The Proteomics Center also supports small molecule analysis. We offer services of sample preparation, LC-MS/MS analysis, statistical analysis, and data mining for large-scale proteomic projects. Center directors are available to provide expert consultation on experimental approaches and design.

The Core provides the following services (see Services & Experiments page for detail description of each service):

Mass Spectrometry-based proteomic analyses

Shotgun proteomics analysis for protein identification
1D LC-MS/MS and multidimensional protein identification technology (MudPIT)
Intact protein analysis by MALDI
Relative & absolute protein quantification (15N SILAM, SILAC, iTRAQ, TMT, label-free, etc.)
Post-translational modification (PTM) analysis

Small molecule and DNA analysis

Check out the newest papers containing data produced in the Proteomics Center:

Early-stage epigenetic modification during smatic cell reprogramming by Parp1 and Tet2. (2012) Doege CA, Inoue K, Yamashita T, Rhee DB, Travis S, Fujita R., Guarnieri P, Bhagat G, Vanti WB, Shih A, Levine RL, Nik S, Chen EI, Abeliovich A. Nature in press.

Gamma-Synuclein interacts with Phospholipase Cbeta2 to Modulate G Protein Activation. (2012) Golebiewska U, Guo Y, Khalikaprasad N, Zurawsky C, Yerramilli VS, Scarlata S. PlosOne

Detecting The Immune System Response Of A 500 Year-old Inca Mummy. (2012) Corthals A, Koller A, Martin DW, Rieger R, Chen EI, Bernaski M, Recagno G, Davalos LM. PlosOne

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